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(P < 0.001). The depth of sedation was significantly higher in the DK and DF groups than in the MK andMF groups (P < 0.01). DK and DF produced significant intra- and postoperative analgesia when comparedwith combinations of MK and MF. No significant adverse events were observed for any of the combinations.

Conclusions: The DK and DF groups showed potential as analgesio-sedatives in view of their anxiolytic andanalgesic effects.